Micky van de Ven Double Ends The Toffees' Run at Brand New Stadium
Micky van de Ven became the initial backline player to score twice in a Premier League match for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven heads home twice in opening period
The home side's Jake O'Brien has equalizer ruled after VAR review
Pape Matar Sarr nets final goal in 89th minute
The defeat is Everton's first at their new ground
Micky van de Ven found the net twice as Tottenham prolonged their unbeaten run on the road in the top division and handed Everton their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their last five matches at their new ground at the dockside location, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain the Dutchman pounced on two occasions from set-pieces in the first half to put their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
Jake O'Brien believed he had equalized the scores five minutes after Van de Ven's first goal, glancing a bullet header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, missed a number of chances, while Vicario made a series of excellent stops to guarantee Tottenham went five matches on the road without defeat in the Premier League.
But the VAR intervened, advising the match official to check the score on the screen and the referee ruled that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win moves Thomas Frank's side into third place in the division, a handful of points off local foes and leaders Arsenal.
The Merseyside club remain 14th and sit half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven fulfils duties at both ends of the field
Following a uninspiring midweek display in the Champions League against Monaco, where they mustered a mere attempts on target, Frank opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The summer signing was unable to influence the game before being replaced for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the end.
Centre-back Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder directing the ball back across the six-yard box for an unmarked the defender to score.
And Ven de Ven - filling in as captain in Cristian Romero's unavailability - notched his second in first-half stoppage time as he outjumped the England keeper to nod in.
Van de Ven was equally outstanding in defence, combining well with Kevin Danso as the duo handled superbly with the numerous deliveries sent their way by Everton.
Everton analysis: Toffees lacking finishing touch
The club's recent stadium had been a fortress, but it seems the freshness may have faded slightly and fans flocked to the gates after the midfielder's third for Spurs.
The end in Everton's unbeaten home run will not be a massive concern for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Everton's two recognised strikers - had scored only one league goal between them before the weekend's match.
And they were unable to add to that miserable tally on a wet and gloomy night on in Liverpool.
The striker's form was epitomized when he chose to bicycle-kick a golden opportunity from near the goal, despite having space and time to reposition for a more conventional attempt that would have tested Vicario.
Barry, as well, was unable to make an impact after replacing Beto in the second half.
It wasn't for a shortage of opportunity. The majority of the home side's offensive moves came through Grealish and Ndiaye, who relentlessly delivered threatening balls into the Tottenham box.
What next for both teams?
The Toffees: Moyes' men travel to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: Spurs travel to St James' Park on late October for their fourth-round Carabao Cup tie against Newcastle.